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Sulfatrim Oral Drops 30ml

VIRBAC

Item no: SULFATRIM
 
Sulfatrim Oral Drops for Rabbits, Pigeons and Bearded Dragons 30ml. For the treatment of gastrointestinal infections caused by protozoa (namely coccidian) sensitive to the combination of trimethoprim and sulfamethoxazole.
Prescription Medicine
Max 1 per customer
£9.29
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Sulfatrim Oral Drops for Rabbits, Pigeons and Bearded Dragons 30ml.

Target species Rabbits, pigeons and bearded dragons

Indications for use
Treatment of gastrointestinal infections caused by protozoa (namely coccidian) sensitive to the combination of trimethoprim and sulfamethoxazole.

Contra-indications
Do not use in cases with severe renal or hepatic impairment.
Do not use the product for prophylaxis.
Do not use in cases of known hypersensitivity to the active substances or the excipients.

Special warnings for each target species
This is a limited marketing authorisation and efficacy of the product is supported by a very small amount of data for the above indications. Suspected lack of efficacy of the product must be reported to the Marketing Authorisation Holder or the Veterinary Medicines Directorate.
As with all other anti-infectives, prolonged use may result in the development
of resistant strains.

Special precautions for use
Special precautions for use in animals
Maintain patient hydration during treatment.
The product should be used with caution in patients with diminished renal or hepatic function, or urinary obstruction, due to the possible increased risk of side effects as a result of decreased drug clearance.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to sulfonamides should avoid contact with the veterinary medicinal product.
In case of reaction of hypersensitivity after exposure (such as skin rash), seek medical advice and show the package leaflet or the label to the physician. In case of severe reactions (swelling of the face, lips or eyes), seek prompt medical attention and take the package leaflet with you.
Take care to avoid direct contact with skin and eyes. If contact occurs, wash affected area with copious amounts of clean water. Seek medical advice if irritation persists.
Wash hands after use.

Adverse reactions
Sulfonamides can cause various hypersensitivity reactions or signs of gastrointestinal disease by altering the normal gut flora.Regurgitation may be seen in birds.
CNS stimulation and myelin degeneration have been noted after very high dosages.

Use during pregnancy, lactation or lay
No studies of use of the product in pregnant or lactating animals have been conducted. Sulfonamides cross the placenta and may reach foetal levels of 50% or greater of those found in maternal serum; teratogenicity has been reported in some laboratory animals when given at very high doses. Both active substances cross the placenta and are distributed in milk. They should be used in pregnant animals only when the benefit: risk assessment by the responsible veterinarian indicates that benefits clearly outweigh the risks of therapy.

Interactions
Antacids may decrease the oral bioavailability of sulfonamides if administered concurrently.
Sulfonamides may give false-positive results for urine glucose determinations when using the Benedict's method.

Amounts to be administered and administration route
For oral administration.
To ensure a correct dosage, bodyweight should be determined as accurately as possible to avoid under-dosing.
Species
Dose (mg/ml)TMP+SMZ
Frequnecy daily
ml solution /kg
Duration (days)
Rabbits
20-30
2
0.2-0.3
10-14
Pigeon
25-50
2
0.2-0.5
10-14
Bearded Dragons
15-20
1*
0.15-0.2
7-14
* Some literature advises alternate day dosing after the second dose has been administered.
This is a limited marketing authorisation and the above dosages are in accordance with those reported for the active substances in the target species. Any suspected adverse events or suspected lack of efficacy must be reported to Virbac Ltd (UK distributors) or the Veterinary Medicines Directorate.

Overdose
Sulfonamides (or their metabolites) can precipitate in the urine, particularly when given at high dosages for prolonged periods. Acidic urine or highly concentrated urine may also contribute to increased risk of crystalluria, haematuria and renal tubule obstruction.

Withdrawal periods
Do not use the product in animals intended for human consumption or in those animals producing eggs for human consumption.

Pharmacological particulars
Pharmacodynamic properties
Sulfamethoxazole acts as a false substrate in the synthesis of folic acid and trimethoprim inhibits dihydrofolate reductase. In combination, the effect is synergistic and inhibits sequential steps in the synthesis of tetrahydrofolic acid.

Pharmacokinetic properties
Sulamethoxazole is a weak organic acid and trimethoprim is a lipid-soluble organic base. Each drug has different pharmacokinetic parameters (absorption, distribution, elimination) in each species. In combination, they are thought to be well distributed throughout the body. They are renally excreted unchanged via glomerular filtration and tubular secretion and metabolised by the liver. Sulfonamides are primarily acylated and conjugated with glucuronic acid and trimethoprim is metabolised to oxide and hydroxylated metabolites.

Pharmaceutical particulars
Excipients
Coconut aroma
Sodium hydroxide
Glycerol
Glycerol formal
Water for injections

Major incompatibilities
Do not mix this product with other veterinary medicinal products.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years
Shelf-life after first opening the immediate packaging: do not use after treatment (max 10 days) has finished.
Shelf-life after dilution or reconstitution according to directions: 4 hours.

Special precautions for storage
Do not store above 25°C.
Do not refrigerate or freeze.
Protect from light.
Store in the original container.
Following dilution in tap water, any medicated water remaining after 4 hours should be discarded.
Immediate packaging
30 ml brown glass bottle (Class 3) with a low density polyethylene syringe insert and a high density polyethylene dropper screw-cap.

Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
 

Shipping charges mainland UK zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250g £2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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