Tylan POM

Description
Data Sheets
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Qualitative and quantitative composition

Each 1.1g of the veterinary medicinal product contains

Active substance:

1000mg of tylosin (equivalent to 1100mg of tylosin tartrate)

Pharmaceutical form

Powder for oral solution

A white to medium yellow powder.

Clinical particulars

Target species

For use in calves, pigs, chickens and turkeys .

Indications for use, specifying the target species

For the control of Mycoplasma synoviae airsacculitis in chickens and Mycoplasma gallisepticum S6 in chickens and turkeys. In the field tylosin has also proved useful in reducing the level of infection following stress associated with live vaccination.

As an aid in the control of outbreaks of necrotic enteritis in chickens caused by Clostridium perfringens.

For the prevention and control of enzootic pneumonia, and scours caused by organisms (e.g. Lawsonia intracellularis) sensitive to tylosin, in pigs.

For the control of pneumonia in cattle associated with mycoplasmata and Pasteurella multocida sensitive to tylosin.

For information regarding swine dysentery see section Special precautions for use.

Contraindications

Do not use in cases of hypersensitivity to the active substance or other macrolides.

Special warnings for each target species

None

Special precautions for use

Special precautions for use in the target species

Use of the product be based on identification and susceptibility testing of the target pathogen(s). If this is not possible, therapy should be based on epidemiological information and knowledge of susceptibility of the target pathogens at farm level, or at local/regional level.

Use of the product should be in accordance with official, national and regional antimicrobial policies.

A high rate of in vitro resistance has been demonstrated in European strains of Brachyspira hyodysenteriae implying that the product will not be sufficiently efficacious against swine dysentery.

Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to tylosin and may decrease the effectiveness of treatment with other macrolides, lincosamides and streptogramin B due to the potential for cross-resistance.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.

To avoid exposure during preparation of the medicated drinking water, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143. Wash hands after use.

In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.

Do not handle the product if you are allergic to ingredients in the product.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Adverse reactions (frequency and seriousness)

None known

Use during pregnancy, lactation or lay

No adverse effects to tylosin have been seen in fertility, multi-generation or teratology studies.

Interaction with other medicinal products and other forms of interaction

None known

Amounts to be administered and administration route

For oral administration through drinking water.

In calves, the veterinary medicinal product corresponds to 1 gram of tylosin. The dosages are as follows:

Chickens and turkeys:
For the control of chronic respiratory disease: 50-200mg tylosin per kg BW per day (corresponding to 55-220mg of the veterinary medicinal product per kg BW) for 5 days.

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridium perfringens in chickens: 20-50 mg/kg tylosin per/kg BW per day (corresponding to 22-55mg of the veterinary medicinal product per kg BW), depending on the age and the water consumption of the birds.

Pigs:

For the treatment of enzootic pneumonia: 25 mg tylosin/kg BW (corresponding to 27.5 mg of the veterinary medicinal product per kg BW). A medicated solution of drinking water should generally be administered until 24 hours after scouring or respiratory symptoms have ceased, normally 3-10 days. The diagnosis should be reviewed if there is no response after 5 days of medication.

For the treatment of ileitis:

5 – 10 mg tylosin per kg BW per day (corresponding to 5.5 – 11 mg of the veterinary medicinal product per kg BW) for 3 – 10 days.

Calves:

1.1 g of the veterinary medicinal product should be incorporated in milk or milk replacer twice daily for each calf. This should be continued for 7-14 days dependent on response.

The intake of medicated water/milk/milk replacer depends on the clinical condition of the animals. In order to obtain the correct dosage, the concentration of tylosin may need to be adjusted accordingly.

To ensure a correct dosage, body weight should be determined as accurately as possible.

Based on the recommended dose and the number and weight of animals to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:

......mg veterinary medicinal product per kg body weight per day	X	average body weight (kg) of animals to be treated
			=......mg veterinary medicinal product per litre of drinking water or milk
	average daily water or milk intake (l/animal)

Overdose (symptoms, emergency procedures, antidotes), if necessary

There is no evidence of tylosin toxicity in animals, at dose rates of up to 1000 mg/kg.

Withdrawal periods

Animals must not be slaughtered for human consumption during treatment.

Chickens, when the veterinary medicinal product is used for the control of chronic respiratory disease:

Meat and offal: 1 day

Eggs: Zero days

Chickens, when the veterinary medicinal product is used as an aid in the control of outbreaks of necrotic enteritis caused by Clostridium perfringens (Meat, offal and eggs): Zero days

Turkeys (meat and offal): Zero days

Pigs (meat and offal): Zero days

Calves (meat and offal): 14 days

Pharmacological particulars

Pharmacotherapeutic group: Macrolides, ATCvet code: QJ01FA90

Pharmacodynamic properties

Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.

The tylosin spectrum of activity includes Gram-positive bacteria including Clostridium perfringens and some Gram-negative strains such as Pasteurella and Mycoplasma spp. at concentrations of 16µg/ml or less.

Pharmacokinetic particulars

Absorption: Tylosin reaches maximal blood levels between 1 and 3 hours after an oral dose. Minimal or no blood levels remain 24 hours after an oral dose.

Distribution: After oral doses were given to pigs, tylosin was found in all tissues, between 30 minutes and two hours after administration, except for the brain and spinal cord.

Biotransformation and Elimination: It has been shown that most of the material which is excreted is to be found in the faeces and consists of tylosin (factor A), relomycin (factor D) and dihydrodesmycosin.

Data-Sheet-TYLAN-8520.pdf Data-Sheet-TYLAN-8492.pdf

Shipping charges mainland GB zone1

Value	Weight	Delivery Charge
Over £49.00	Any Weight	FREE
Under £49.00	No weight limit	£4.50
Under £49.00	Under 250 grams	£3.49

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.

Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

We no longer send goods outside of the UK.

Prescription Items

Prescription items will be sent on receipt of a legally valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated lines Packaging Cost: Despatched with Woolcool Refrigerated Packaging for £7.50.

Wool cool keeps pharmaceutical products at fridge-like, ambient, or even freezing temperatures for up to 72 hours, and possibly longer depending on the contents and use of ice packs.

Important Delivery Information:

Receipt Required: Someone must be available to receive the delivery. Woolcool packaging is designed for temperature-controlled goods, so parcels cannot be left unattended.
Immediate Refrigeration: Upon receipt, refrigerate the contents immediately to ensure your food or medicine remains at the correct temperature.
Failed Delivery Attempts: We are not responsible for the cost of replacements if a delivery attempt fails due to the absence of someone to receive it.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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