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Ketodolor 100mg/ml injection 100ml


Prescription Medicine
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Ketodolor 100mg/ml injection for horses, cattle and pigs.

Target species: Horses, cattle, pigs

Indications for use,specifying the target species
- alleviation of inflammation and pain associated with musculoskeletal disorders
- alleviation of visceral pain associated with colic.
- alleviation of pain (e.g. from pressure trauma) resulting from parturient paresis;
- reducing the pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy as appropriate;
- improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis, caused by gram negative micro-organisms, in conjunction with antimicrobial therapy;
- alleviation of pain associated with udder oedema following calving.
- reducing pain associated with lameness.
- reducing the pyrexia and respiratory rate associated with bacterial or viral respiratory disease when used in conjunction with antimicrobial therapy as appropriate.
- the supportive treatment of Mastitis Metritis Agalactia Syndrome in sows, in conjunction with antimicrobial therapy as appropriate.

Contraindications - Do not use in horses, cattle or pigs that have previously shown a hypersensitivity to ketoprofen.
Do not use other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other.
Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastro-intestinal ulceration or bleeding, where there is evidence of a blood dyscrasia or hypersensitivity to the product.

Special warnings for each target species - None

Special precautions for use in animals - Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided animals may require a reduced dosage and careful management. The use of ketoprofen is not recommended in foals under the age of 15 days.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.
Avoid intra-arterial injection. Do not exceed the stated dose or duration of treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals - In case of accidental self-injection seek medical advice and show the package leaflet or the label to the physician. People with known hypersensitivity to the active substance and/or benzyl alcohol should avoid contact with the product. Avoid splashes on the skin and eyes. Wash the affected area thoroughly with water should this occur. If irritation persists seek medical advice. Wash hands after use.

Adverse reactions - In common with all NSAIDs, due to their action of inhibition of prostaglandin synthesis, there can be the possibility in certain individuals of gastric or renal intolerance.
Use during pregnancy, lactation or lay - The safety of ketoprofen has been investigated in pregnant laboratory animals, (rats, mice and rabbits) and in cattle, and showed no teratogenic or embryotoxic effects. The product may be given to pregnant and to lactating cattle, and to lactating sows. As the effects of ketoprofen on the fertility, pregnancy or foetal health of horses have not been determined, the product should not be administered to pregnant horses.
As the safety of ketoprofen has not been assessed in pregnant sows, the product should be used in these cases according to a benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction - Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects. Concurrent administration with nephrotoxic drugs should be avoided.
Concurrent administration of other steroidal or non-steroidal anti-inflammatory drugs, diuretics or anticoagulant agents may lead to potentiating adverse effects. A treatment free period, dependent on the product administered, should be observed between such treatments."

Amounts to be administered and administration route
For use in musculo-skeletal conditions, the recommended dosage is 2.2 mg ketoprofen/kg i.e. 1ml of the product /45kg body weight, administered by intravenous injection once daily for up to 3 to 5 days.
For use in equine colic, the recommended dosage is 2.2mg/kg (1ml/45kg) body weight, given by intravenous injection for immediate effect. A second injection may be given if colic recurs.
The recommended dose is 3mg ketoprofen/kg body weight, i.e. 1ml of the product/33kg body weight, administered by intravenous or deep intramuscular injection once daily for up to 3 days.
The recommended dose is 3mg ketoprofen/kg body weight, i.e. 1ml of the product /33kg body weight, administered once by deep intramuscular injection
The stopper cannot be punctured more than 20 times.
Overdose - No clinical signs were observed when ketoprofen was administered to horses at 5 times the recommended dose for 15 days, to cattle at 5 times the recommended dose for 5 days, or to pigs at 3 times the recommended dose for 3 days.

Withdrawal period(s)
meat & offal: following intravenous administration - 1 day ; following intramuscular administration - 4 days
milk: zero hours
meat & offal: 4 days
meat & offal: 1 day
milk: not authorized for use in lactating animals producing milk for human consumption.

Pharmacological particulars
Pharmacodynamic properties - Ketoprofen is a derivative of phenylpropionic acid, and belongs to the non steroidal anti-inflammatory group of drugs. Like all such substances, its principal pharmacological actions are anti-inflammatory, analgesic and anti pyretic. The mechanism of action is related to the ability of ketoprofen to interfere with the synthesis of prostaglandins from precursors such as arachidonic acid.
Following intravenous injection in the horse, the onset of musculo-skeletal anti-inflammatory activity occurs by 2 hours, and reaches a peak at about 12 hours. It is still measurable 24 hours after each dose.

Pharmacokinetic particulars - Ketoprofen binds 95% to plasma proteins.
Pharmaceutical particulars
List of excipients - Benzyl alcohol (E1519), L-arginine, Citric acid monohydrate (for pH adjustment), Water for injections
Incompatibilities - In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life after first opening the immediate packaging: 28 days

Special precautions for storage - Do not refrigerate or freeze. Keep the vial in the outer carton in order to protect from light.
Nature and composition of immediate packaging - The product is packed in amber type II glass vials of 50 ml or 100 ml, fitted with red chlorobutyl stoppers and aluminium caps. Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Shipping charges mainland GB zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250 grams £3.49

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.

Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

We no longer send goods outside of the UK.

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or express delivery at a cost of £7.50, with coolpacks, unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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