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Halocur 0.5 mg/ml oral solution for calves

MSD

Item no: HALOCUR
 
Prescription Medicine
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  • 490ml
  • 980ml
  • 980ml Refill
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£118.79 - £198.59
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Target Species
New born calves.
Indications for use
Prevention of diarrhoea due to diagnosed Cryptosporidium parvum, in farms with history of cryptosporidiosis.
Administration should start in the first 24 to 48 hours of age.
Reduction of diarrhoea due to diagnosed Cryptosporidium parvum.
Administration should start within 24 hours after the onset of diarrhoea.
In both cases, the reduction of oocysts excretion has been demonstrated.
Contraindications
Do not use on an empty stomach.
Do not use in case of diarrhoea established for more than 24 hours and in weak animals.
Special warnings for each target species
None.
Special precautions for use
Administer after colostrum feeding, or after milk or milk replacer feeding only, using either a syringe or any appropriate device for oral administration. Do not use on an empty stomach. For treatment of anorexic calves, the product should be administered in half a litre of an electrolyte solution. The animals should receive enough colostrum according to good breeding practice.
Operator warnings
Repetitive contact with the product may lead to skin allergies. Avoid skin, eye or mucosal contact with the product. Wear protective gloves while handling the product.
In case of skin and eye contact wash the exposed area thoroughly with clean water. If eye irritation persists, seek medical advice.
Wash hands after use.
Adverse Reactions
An increase in the level of diarrhoea has been observed in treated animals in very rare cases.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Use during pregnancy or lactation
Not applicable.
Interactions
None known.
Amounts to be administered and administration route
For oral use in calves after feeding.
The dosage is: 100µg of halofuginone base / kg body weight (BW) / once a day for 7 consecutive days, i.e. 2 ml of HALOCUR / 10 kg BW / once a day for 7 consecutive days.
However, in order to make the HALOCUR treatment easier, a simplified dosage scheme is proposed:
•35 kg & calves = 45 kg: 8 ml of HALOCUR once a day during 7 consecutive days
•45 kg &l calves & 60 kg: 12 ml of HALOCUR once a day during 7 consecutive days
For smaller or higher weights, a precise calculation should be performed (2 ml/10 kg BW).
To ensure a correct dosage, the use of either a syringe or any appropriate device for oral administration is necessary.
The consecutive treatment should be done at the same time each day.
Once the first calf has been treated, all the forthcoming new-born calves must be systematically treated as long as the risk for diarrhoea due to C. parvum persists.
Overdose
As symptoms of toxicity may occur at twice the therapeutic dose, it is necessary to apply the recommended dosage strictly. Symptoms of toxicity include diarrhoea, visible blood in faeces, decline in milk consumption, dehydration, apathy and prostration. Should clinical signs of overdosing occur the treatment must be stopped immediately and the animal fed unmedicated milk or milk replacer. Rehydration may be necessary.
Withdrawal periods
Meat and offal: 13 days
Pharmacological particulars
ATC Vet Code: QP51AX08
Pharmacotherapeutic group: Quinazolinone derivate
Pharmacodynamic properties
The active substance, halofuginone, is an antiprotozoal agent of the quinazolinone derivatives group (nitrogenous polyheterocycles). Halofuginone lactate (RU 38788) is a salt whose antiprotozoal properties and efficacy against Cryptosporidium parvum have been demonstrated both in in vitro conditions and in artificial and natural infections. The compound has a cryptosporidiostatic effect on Cryptosporidium parvum. It is mainly active on the free stages of the parasite (sporozoïte, merozoïte). The concentrations to inhibit 50 % and 90 % of the parasites, in an in vitro test system, are IC50 less than 0.1µg/ml and IC90 of 4.5µg/ml respectively.
Pharmacokinetic particulars
The bioavailability of the drug in the calf, following single oral administration, is about 80 %. The time necessary to obtain the maximum concentration Tmax is 11 hours. The maximum concentration in plasma Cmax is 4 ng/ml. The apparent volume of distribution is 10 l/kg. The plasmatic concentrations of halofuginone after repeated oral administrations are comparable to the pharmacokinetic pattern after single oral treatment. Unchanged Halofuginone is the major component in the tissues. Highest values have been found in the liver and the kidney. The product is mainly excreted in the urine. The terminal elimination half-life is 11.7 hours after intravenous administration and 30.84 hours after single oral administration.
Pharmaceutical particulars
Excipients
Benzoic acid (E 210)
Tartrazine (E 102)
Lactic acid (E 270)
Water, purified
Major incompatibilities
None known.
Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf-life after first opening the container: 6 months.
Special precautions for storage
This medicinal product does not require any special storage conditions.
Immediate packaging
High-density polyethylene portable bottle of 500 ml containing 490 ml of the oral solution.
High-density polyethylene portable bottle of 1000 ml containing 980 ml of the oral solution.
Not all pack sizes may be marketed.
Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with the local requirements.
HALOCUR should not enter water courses, as this may be dangerous for fish and other aquatic organisms.

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