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Eprecis 20 mg/ml solution for injection for cattle


Eprecis 20 mg/ml solution for injection for cattle. For the treatment of infestations by internal and external parasites sensitive to eprinomectin.
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Eprecis 20 mg/ml solution for injection for cattle.

Treatment of infestations by the following internal and external parasites sensitive to eprinomectin:
Gastrointestinal roundworms:
Ostertagia ostertagi - Adult, L4 & Inhibited L4 stages.
Ostertagia lyrata - Adult stages.
Ostertagia spp. - Adult & L4 stages.
Cooperia oncophora - Adult & L4 stages.
Cooperia pectinata - Adult & L4 stages.
Cooperia surnabada - Adult & L4 stages.
Cooperia punctata - Adult & L4 stages.
Cooperia spp. - Adult, L4 & Inhibited L4 stages.
Haemonchus placei - Adult & L4 stages.
Trichostrongylus axei - Adult & L4 stages.
Trichostrongylus colubriformis - Adult & L4 stages.
Trichostrongylus spp. - Adult & L4 stages.
Bunostomun phlebotomum - Adult & L4 stages.
Nematodirus helvetianus - Adult & L4 stages.
Oesophagostomum radiatum - Adult & L4 stages.
Oesophagostomum spp. - Adult stages.
Trichuris spp. - Adult stages.
Dictyocaulus viviparus - Adult & L4 stages.
External parasites:
Warbles (parasitic stages): Hypoderma bovis, Hypoderma lineatum;
Mange mites: Sarcoptes scabiei var. bovis;
Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus;
Horn flies: Haematobia irritans.

Prevention of reinfestations:
The product protects the animals against reinfestations with:
- Trichostrongylus spp. (including Trichostrongylus axei and Trichostrongylus colubriformis), Haemonchus placei, Cooperia spp. (including Cooperia oncophora, Cooperia punctata, Cooperia surnabada), Dictyocaulus viviparus, Oesophagostomum radiatum, Ostertagia spp. (including Ostertagia ostertagi and Ostertagia lyrata) and Nematodirus helvetianus for 14 days.
- Haematobia irritans for at least 7 days.

Dosage and administration
Subcutaneous use.
Single administration of 0.2 mg of eprinomectin per kg bodyweight; corresponding to 1ml of the veterinary medicinal product per 100 kg bodyweight.
50 ml and 100 ml vials: Do not exceed 30 broachings per vial. If more than 30 broachings are required, use of a draw off needle is recommended.
250 ml and 500 ml vials: Do not exceed 20 broachings per vial. If more than 20 broachings are required, use of a draw off needle is recommended.

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible and accuracy of the dosing device should be checked.
Do not use in other animal species.
Do not use in case of hypersensitivity to active substance or to any of the excipients.

Special warnings
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported within the EU. However resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU. Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for use in animals
Usual aseptic procedures for administration of a parenteral injection should be followed.
Not to be used in other species; avermectins can cause fatalities in dogs, especially Collies, Old English Sheepdogs and related breeds and crosses, and also in turtles/tortoises.
To avoid adverse reactions due to the death of warble larvae in the oesophagus or backbone, it is recommended to administer the product after the end of warble fly activity and before the larvae reach their resting sites in the body; consult a veterinary surgeon regarding the appropriate time for treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
The veterinary medicinal product causes serious eye irritation. Avoid contact with the eyes. Wash any splashes from eyes immediately with water.
This product may cause neurotoxicity. Care should be taken when handling the product to avoid self-injection. In case of accidental injection, seek medical advice immediately and show the package leaflet or the label to the physician.
Avoid contact with the skin. Wash any splashes from skin immediately with water.
Avoid oral exposure. Do not eat, drink or smoke while handling the veterinary medicinal product.
Wash hands after use.

The excipient glycerol formal may cause harm to the unborn child. In addition, the active substance eprinomectin can be transferred to breast milk. Pregnant/breast-feeding women and women of childbearing age should therefore avoid exposure to this product.
Do not use the product in known cases of sensitivity to the active substance or to any of the excipients.

Other precautions
Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. Eprinomectin is very toxic to aquatic organisms, is persistent in soils and may accumulate in sediments. The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of eprinomectin (and products of the same anthelmintic class) in cattle and will be further reduced by keeping treated cattle away from water bodies for two to five weeks after treatment. Following treatment, excretion of potentially toxic levels of eprinomectin may take place over a period of several weeks. Faeces containing eprinomectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation.

Adverse reactions
Following treatment, moderate to severe swelling at the site of injection is very common. Typically, the swelling resolves within 7 days, but induration (hardness) may persist for in excess of 21 days. Swelling may be associated with mild to moderate pain.
This reaction disappears without any treatment and does not impair the safety or efficacy of the veterinary medicinal product.

Use during pregnancy, lactation or lay
Can be used during pregnancy and lactation.

Interaction with other medicinal products and other forms of
Since eprinomectin binds strongly to plasma proteins, this should be taken into account if it is used in association with other molecules having the same characteristics.

After subcutaneous administration of up to 5 times the recommended dose, no adverse events were observed except a transient reaction (swelling followed by induration) at the injection site.

Withdrawal period
Meat and offal: 63 days
Milk: zero hours.
Pharmaceutical precautions

Special precautions for storage
This veterinary medicinal product does not require any special storage conditions.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf-life after first opening the immediate packaging: 6 months.
Legal category
Legal category: POM-VPS

Packaging quantities
50 ml vial
100 ml vial
250 ml vial
500 ml vial
Not all pack sizes may be marketed.

Further information
Pharmacotherapeutic group: endectocides, macrocyclic lactones, avermectins.
ATC vet code: QP54AA04

Pharmacodynamic properties
Eprinomectin is a member of the macrocyclic lactone class of endectocides. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.

Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels; the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels, and they do not readily cross the blood-brain barrier.

Pharmacokinetic particulars
Following subcutaneous administration, the bioavailability of eprinomectin is about 89%. The maximal mean plasma concentration of 58 µg/L was reached after 36-48 h.

There is a linear relationship between the dose administered and plasma concentration observed in the therapeutic dose range from 0.1 to 0.4 mg/kg. Eprinomectin is highly bound (greater than 99%) to cattle plasma proteins.

Eprinomectin is not extensively metabolised in cattle. Metabolites amount to approximately 10% of the total residues in plasma, milk, edible tissues and faeces.

Eprinomectin is eliminated with a half-life of 65-75 h and the major route of elimination is via faeces.

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