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Cepritect 250mg Intramammary Suspension for Dry Cows (pack of 120)

Norbrook

Item no: CEPRITEC
 
Prescription Medicine
Max 1 per customer
Was: £376.85
Now: £348.39
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Target species
Dairy cattle (dry cow)
Indications for use, specifying the target species
For the treatment of subclinical mastitis at drying-off and the prevention of new bacterial infections of the udder during the non-lactating period of cows caused by Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Trueperella pyogenes, Escherichia coli and Klebsiella spp. susceptible to cefalonium.
Contraindications
Do not use in animals with known hypersensitivity to cephalosporins, other ß-lactam antibiotics or to any of the excipients. Please refer to section, Use during pregnancy, lactation or lay
Special warnings for each target species
None.
Special precautions for use
Special precautions for use in animals
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to cefalonium and may decrease the effectiveness of treatment with other beta lactams.
The efficacy of the product is only established against the pathogens mentioned in section, Indications for use, specifying the target species of the SPC. Consequently, serious acute mastitis (potentially fatal) due to other pathogen species, particularly Pseudomonas aeruginosa, can occur after drying off. Good hygienic practices should be thoroughly respected in order to reduce this risk.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
Penicillin and cephalosporins may cause sensitisation (allergy) following injection, inhalation, ingestion or skin contact. Sensitivity to penicillin may lead to cross-sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended precautions.
If you develop symptoms following exposure such as a skin rash you should seek medical advice and show the doctor this warning. Swellings of the face, lips or eyes or difficulty breathing are more serious symptoms and require urgent medical attention.
The cleaning towels provided with the intramammary product contain isopropyl alcohol. Wear protective gloves if skin irritation due to isopropyl alcohol is known or suspected. Avoid contact with eyes because isopropyl alcohol can cause eye irritation.
Adverse reactions (frequency and seriousness)
In very rare cases immediate hypersensitivity reactions were observed in some animals (restlessness, tremors, swelling of mammary gland, eyelids and lips). These reactions can lead to death.
The frequency of adverse reactions is defined using the following convention:
•very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
•common (more than 1 but less than 10 animals in 100 animals)
•uncommon (more than 1 but less than 10 animals in 1,000 animals )
•rare (more than 1 but less than 10 animals in 10,000 animals)
•very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Intended for use during the last trimester of pregnancy once the lactating cow has been dried off. There is no adverse treatment effect on the foetus.
Not to be used in cows that are lactating.
Interaction with other medicinal products and other forms of interaction
Cephalosporins should not be administered concurrently with bacteriostatic antimicrobials. Concomitant use of cephalosporins and nephrotoxic drugs may increase renal toxicity.
Amounts to be administered and administration route
For intramammary use.
The contents of one syringe should be infused into the teat canal of each quarter immediately after the last milking of the lactation. Avoid contamination of the nozzle after removing the cap. Before infusion, thoroughly clean and disinfect the end of the teat with the cleaning towel provided.
Option 1: For short nozzle intramammary administration hold the barrel of the syringe and the base of the cap in one hand and twist off the small upper part of the cap above the indent mark (the base portion of the cap remains on the syringe). Take care not to contaminate the short exposed part of the nozzle.
Description: Cepritect-Option1
Option 2: For full nozzle intramammary administration remove the cap fully by holding the barrel of the syringe firmly in one hand and with the thumb push up and along the length of the cap until the cap clicks off. Take care not to contaminate the nozzle.
Description: Cepritect-Option2
Insert the nozzle into the teat canal and apply steady pressure on the syringe plunger until the full dose has been delivered. Holding the end of the teat with one hand, gently massage upwards with the other to aid dispersion of the antibiotic into the quarter.
After infusion it is advisable to dip the teats in an antiseptic preparation specifically designed for this purpose.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Repeated doses in cattle on three consecutive days did not demonstrate or produce any adverse effects.
Withdrawal period(s)
Meat and offal: 21 days
Milk: 96 hours after calving if the dry period is longer than 54 days. 58 days following treatment if the dry period is less than or equal to 54 days.
Pharmacological particulars
Pharmacotherapeutic group: Antibacterials for intramammary use, first-generation cephalosporins.
ATCvet code: QJ51DB90.
Pharmacodynamic properties
Cefalonium is an antibacterial drug of the first generation cephalosporin group which acts by inhibition of cell wall synthesis (bactericidal mode of action). The antibacterial activity is not impaired in the presence of milk.
Three mechanisms of resistance to cephalosporin are known: reduced permeability of the cell wall, enzymatic inactivation and absence of specific penicillin binding sites. In Gram-positive bacteria and particularly staphylococci, the main cephalosporin resistance mechanism is through alteration of penicillin binding proteins. In Gram-negative bacteria resistance may consist in the production of ß-lactamases, especially extended-spectrum ß-lactamases.
Cefalonium is active against: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Trueperella pyogenes, Escherichia coli and Klebsiella spp.
Pharmacokinetic particulars
Cefalonium is extensively but slowly absorbed from the udder and excreted primarily in the urine. Between 7 and 13% of the active substance is eliminated in urine on each of the first three days post dosing whilst daily excretion in faeces is <1% over the same period.
Mean blood concentration remains fairly constant during approximately 10 days after dosing which is consistent with slow but prolonged absorption of cefalonium from the udder.
The long term persistence of cefalonium in the dry udder was examined over a time span of 10 weeks after infusion. Effective levels of Cefalonium in udder secreta remain up to 10 weeks after infusion.
Pharmaceutical particulars
List of excipients
•Aluminium distearate
•Liquid paraffin
Major incompatibilities
None known
Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage
Do not store above 25°C.
Nature and composition of immediate packaging
Single dose 3g white LDPE syringes with a white LDPE dual push-fit cap.
Cartons of 24 and 60 syringes or buckets of 120 syringes including 24, 60 or 120 individually wrapped teat cleaning towels containing isopropyl alcohol.
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

 

Shipping charges mainland GB zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250 grams £3.49

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We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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