Treatment of urinary incontinence caused by urethral sphincter mechanism incompetence in ovariohysterectomised female dogs.
For oral use.
The tablets can be divided into 2 equal parts to ensure accurate dosing.
The recommended starting dose is 2 mg ephedrine hydrochloride (corresponding to 1.64 mg of ephedrine) per kg bodyweight (BW), equivalent to 1 tablet per 25 kg BW, per day during the first 10 days of treatment. The daily dose may be divided. Once the desired effect has been achieved, the dose can be reduced to one half or less. Based on the observed effect and taking into account the occurrence of adverse effects, the individual dose should be adjusted to find the lowest effective dose. The lowest effective dose should be maintained for long-term treatment. In case of a relapse, the dose should be increased to 2 mg ephedrine hydrochloride per kg BW again. Once the effective dose has been established, dogs should still be monitored at regular intervals. This tablet strength is not appropriate for dogs weighing less than 12.5 kg (recommended starting dose of 2 mg/kg).
Contraindications
Do not use in dogs with cardiovascular disease (i.e. cardiomyopathy, tachycardic arrhythmia, hypertension), hyperthyroidism, diabetes mellitus, impaired renal function or glaucoma.
Do not use concurrently with halogenated narcotics such as halothane or methoxyflurane (see section 4.8). Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Warnings
It is not appropriate to use the product for the behavioural cause of inappropriate urination.
In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment. It is important to identify any underlying disease causing Polyuria/Polydipsia (PU/PD) which may be falsely diagnosed as urinary incontinence.
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