Bioestrovet 0.250mg/ml solution for injection for Cattle 20ml .
Uses
Cattle (heifers, cows):
- Induction of luteolysis allowing resumption of oestrus and ovulation in cyclic females when used during dioestrus
- Synchronisation of oestrus (within 2 to 5 days) in groups of cyclic females treated simultaneously
- Treatment of suboestrus and uterine disorders related to a functioning or persistent corpus luteum (endometritis, pyometra)
- Treatment of ovarian luteal cysts
- Induction of abortion until day 150 of pregnancy
- Expulsion of mummified foetuses
- Induction of parturition
Dosage and administration
Administer by intramuscular injection observing basic aseptic precautions.
0.5 mg cloprostenol/animal corresponding to 2 ml product per animal.
In order to synchronise oestrus in cattle, it is recommended that the product is administered on two occasions with an 11 day interval between treatments.
Termination of abnormal pregnancy: between day 5 and 150 after insemination.
Induction of parturition: within 10 days before the expected date of parturition.
It is recommended that the vial is not broached more than 10 times and that the appropriate vial size is used for prevailing usage conditions. Otherwise, automatic syringe equipment, or a suitable draw-off needle, should be used for the 50 ml and 100 ml vials to avoid excessive puncturing of the stopper.
Contra-indications, warnings, etc
Do not administer to pregnant animals unless the objective is to terminate the pregnancy.
Do not use in animals with cardiovascular, gastro-intestinal or respiratory problems.
Do not administer to induce parturition in cattle with suspected dystocia due to mechanical obstruction or if problems are expected because of an abnormal position of the foetus.
Do not use in case of hypersensitivity to the active substance or to any of the excipients.
Do not administer intravenously.
Special warnings for each target species
There is a refractory period of four to five days after ovulation when cattle are insensitive to the luteolytic effect of prostaglandins.
Special precautions for use
Special precautions for use in animals
In case of oestrus induction in cattle: from the 2nd day after injection, adequate heat detection is necessary.
For the termination of pregnancy, best results are obtained before day 100 of gestation. Results are less reliable between day 100 and 150 of gestation.
Induction of parturition and abortion may increase the risk of complications, retained placenta, foetal death and metritis.
To reduce the risk of anaerobic infections (e.g. swelling, crepitus), which might be related to the pharmacological properties of prostaglandins, care should be taken to avoid injection through contaminated areas of skin. Clean and disinfect injection sites thoroughly before administration.
All animals should receive adequate supervision after treatment.
Adverse reactions (frequency and seriousness)
Localised post-injection bacterial infections, which may become generalised, are occasionally reported.
When used in cattle for induction of parturition and dependent on the time of treatment relative to the date of conception, the incidence of retained placenta may be increased.
In very rare cases, anaphylactic-type reactions can be observed which might be life-threatening and require rapid medical care.
Use during pregnanacy and lactation
Do not administer to pregnant animals unless the objective is to terminate the pregnancy.
The product can be used safely during lactation.
Interaction with other medicinal products and other forms of interaction
Do not administer the product together with non-steroidal anti-inflammatory drugs since they inhibit endogenous prostaglandin synthesis.
The activity of other oxytocic agents can be increased after the administration of cloprostenol.
Overdose
Overdose may be associated with uneasiness and diarrhoea. These effects are usually transient and will resolve without treatment.
Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Pharmaceutical precautions
Shelf life after first opening the immediate packaging: 28 days
Keep the vial in the outer carton in order to protect from light.
This veterinary medicinal product does not require any special temperature storage conditions.
Packaging quantities
20ml Type 1 (colourless) glass vial closed with bromobutyl rubber stopper coated with a teflon film (PTFE) and sealed with a polypropylene flip-off cap.
Shipping charges mainland GB zone1
| Value | Weight | Delivery Charge |
| Over £49.00 | Any Weight | FREE |
| Under £49.00 | No weight limit | £4.50 |
| Under £49.00 | Under 250 grams | £3.49 |
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*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.
