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Anusol Plus HC Suppositories

Item no: ANUSOLHCS
 
Anusol Plus Hc Suppositories are for treating symptoms associated with internal piles (haemorrhoids) and other local skin irritations around the anal area. It relieves discomfort caused by internal and external haemorrhoids and anal itching.
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  • pack of 12
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Was: £6.79
Now: £5.45
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1. Name of the medicinal product Anusol Plus HC Suppositories 2. Qualitative and quantitative composition Anusol Plus HC Suppositories contain: Hydrocortisone acetate Benzyl benzoate Bismuth subgallate Bismuth oxide Balsam peru Zinc oxide 10 mg 33 mg 59 mg 24 mg 49 mg 296 mg For full list of excipients, see section 6.1 3. Pharmaceutical form White/off white Suppository 4. Clinical particulars 4.1 Therapeutic indications Symptomatic treatment of internal haemorrhoids and pruritus ani. 4.2 Posology and method of administration Anal insertion Adults (over 18 years) Remove wrapper and insert one suppository into the anus at night, in the morning and after each evacuation up to a maximum of three per day for a maximum period of one week. Not to be taken orally Elderly (over 65 years) As for adults Children (under 18 years) Not recommended. 4.3 Contraindications Tubercular, fungal and most viral lesions including herpes simplex, vaccinia and varicella. Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1 Do not use in pregnancy or breast-feeding. 4.4 Special warnings and precautions for use Patients with rectal bleeding or blood in the stool should talk to their doctor before using this product as these conditions may be the symptom of a more serious underlying disorder. As with all products containing topical steroids, the possibility of systemic absorption should be borne in mind. Prolonged or excessive use may produce systemic corticosteroid effects, and use for periods longer than seven days is not recommended. Do not use for more than 7 days unless under the direction of a doctor. The product should be discontinued and the patient advised to consult a medical practitioner if symptoms do not improve or worsen or if rectal bleeding occurs. Visual disturbance Visual disturbance may be reported with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids. 4.5 Interaction with other medicinal products and other forms of interaction Concurrent use with other corticosteroid preparations, either topically or orally, may increase the likelihood of systemic effects. Co-treatment with CYP3A inhibitors, including cobicistat containing products, is expected to increase the risk of systemic effects. The combination should be avoided unless the benefit outweighs the increased risk of systemic corticosteroid side-effects, in which case patients should be monitored for systemic corticosteroid side-effects. 4.6 Fertility, pregnancy, and lactation There is inadequate evidence of safety in human pregnancy and there may be a very small risk of cleft palate and intrauterine growth retardation as well as suppression of the neonatal hypothalamic-pituitary-adrenal axis. There is evidence of harmful effects in animals. Do not use in pregnancy or breastfeeding. 4.7 Effects on ability to drive and use machines No effects have been reported on ability to drive or use machinery. 4.8 Undesirable effects No Adverse Drug Reactions (ADRs) have been identified from the analysis of post-marketing data for fixed combinations of Balsam Peru, bismuth oxide and zinc oxide. ADRs identified during Post-Marketing experience with Zinc Oxide (topical use) are included in the Table below. The frequencies are provided according to the following convention: Very common =1/10 Common =1/100 and < 1/10 Uncommon =1/1,000 and <1/100 Rare =1/10,000 and <1/1,000 Very rare <1/10,000 Not known (cannot be estimated from the available data) ADRs are presented by frequency category based on 1) incidence in adequately designed clinical trials or epidemiology studies, if available, or 2) when incidence cannot be estimated, frequency category is listed as 'Not known' System Organ Class (SOC) Frequency Adverse Drug Reaction (Preferred Term) Immune System Disorders Rare Hypersensitivity General Disorders and Administration site conditions Not known Application site reactions (including Burn, erythema, Exfoliation, Irritation, Pain, Pruritus, Rash and Urticaria) Eye Disorders Not known Vision, blurred (see also section 4.4) Other adverse reactions include: Skin sensitisation reactions and systemic contact dermatitis, attributed directly to Balsam Peru have been reported in published literature. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. 4.9 Overdose No overdose related adverse drug reactions have been identified from the post- marketing data analysis of Balsam Peru, benzyl benzoate, bismuth oxide, bismuth subgallate, hydrocortisone acetate and zinc oxide. If swallowed, fever, nausea, vomiting, stomach cramps and diarrhoea may develop 3-12 hours after ingestion. Symptoms of acute oral overdose of bismuth-containing preparations may include nausea, vomiting, renal failure and rarely liver damage. Encephalopathy and discolouration of mucous membranes may occur with chronic overdose. No cases of Balsam Peru overdose have been identified in the medical literature. Hydrocortisone normally does not produce toxic effects in an acute single overdose. Prolonged, use of topical corticosteroids may increase potential for local adverse effects, including steroid atrophy (thinning of the skin), striae (stretch marks), and Telangiectasia (visible blood vessels). Systemic availability after rectal administration is very low, however, excessive administration of corticosteroids may increase the potential for systemic effects, such as hypothalamic-pituitary axis suppression. Treatment of a large acute overdose should include gastric lavage, purgation with magnesium sulphate and complete bed rest. If necessary give oxygen and general supportive measures. Methaemoglobinaemia should be treated by intravenous methylene blue. 5. Pharmacological properties 5.1 Pharmacodynamic properties Pharmacotherapeutic group: Agents for treatment of haemorrhoids and anal fissures for topical use, ATC code: C05A A01 Anusol Plus HC provides antiseptic, astringent, emollient and decongestant properties. In addition, hydrocortisone exerts an anti-inflammatory action. Bismuth oxide, zinc oxide and bismuth subgallate exert a protective action on mucous membranes and raw surfaces. They are mildly astringent and are reported to have antiseptic properties Balsam Peru has protective properties and very mild antiseptic action by virtue of its content of cinnamic and benzoic acids. It is believed to promote the growth of epithelial cells. Benzyl benzoate is used as a solubilizing agent and has mild antiseptic and preservative properties. Hydrocortisone acetate has the general properties of hydrocortisone and the anti- inflammatory action is of primary interest in the product. 5.2 Pharmacokinetic properties Systemic absorption of hydrocortisone acetate from the rectum may occur but estimates of the extent of absorption have been variable and have always been less than 30%. Following absorption it is metabolised in the liver and most body tissues before being excreted in the urine. Biological half-life is approximately 100 minutes and it is 90% bound to plasma protein. The other active ingredients in Anusol HC Plus Suppositories exert their therapeutic effect without being absorbed into the systemic circulation. These observations are supported by evidence from various studies and reviews. 5.3 Preclinical safety data The active ingredients of Anusol are well known constituents of medicinal products and their safety profile is well documented. 6. Pharmaceutical particulars 6.1 List of excipients Kaolin light Hard Fat (Suppocire BS2) 6.2 Incompatibilities No incompatibilities have been reported. 6.3 Shelf life 3 years. 6.4 Special precautions for storage Do not store above 25°C. For storage conditions after first opening of the medicinal product, see section 6.3 6.5 Nature and contents of container Printed strip pack consisting of white opaque PVC/polyethylene laminated film. Each pack contains 12 suppositories. Not all pack sizes may be marketed 6.6 Special precautions for disposal and other handling No special requirements. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

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