*Images are for illustrative purposes only

Vitamin K1 Laboratoire TVM, Solution for Injection for Dogs, 10 mg/ml 5ml (pack of 6)


Item no: VITK1INJ
Prescription Medicine
Max 1 per customer
Adding to basket… The item has been added
Browse other products from the TVM UK range

Vitamin K1 Laboratoire TVM, Solution for Injection for Dogs, 10 mg/ml 5ml. Target species: Dogs.

Indications for use:
In dogs: Emergency treatment of anticoagulant rodenticide poisoning, before starting oral treatment.

Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species:
As the anticoagulant effects of rodenticides are known to be long lasting it is recommended to start Vitamin K1 supplementation with an oral formulation within 12 hours of the last injection for a duration of 3 weeks, and to evaluate the coagulation status (via one stage prothrombin times) 48 hours after the last administration. In the case of persistence of the anticoagulant in the body, the duration of treatment can be extended as long as the anticoagulant persists, to avoid relapse (the coagulation status has to be evaluated 48 hours after each attempt of treatment cessation).

Special precautions for use in animals:
The product should be administered only by a veterinarian. Administer by slow intravenous injection.

The formation of prothrombin may be inadequate when dealing with patients with severe liver dysfunction. Therefore, a careful monitoring of coagulation parameters after administration of vitamin K1 is required.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

People with known hypersensitivity to phytomenadione should avoid contact with the veterinary medicinal product.

Avoid contact with eyes. In the event of accidental contact with the eyes, rinse immediately and thoroughly with tap water, then seek medical advice and show the label to the physician.

In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions:
Some cases of hypersensitivity reactions (anaphylactic-type reactions) have been described.

Use during pregnancy and lactation:
The safety of the veterinary medicinal product has not been established in bitches during pregnancy and lactation. Studies conducted in laboratory animals have shown no teratogenic or foetotoxic effects. Vitamin K1 crosses the placental barrier. Use only according to the benefit/risk assessment by the responsible veterinarian.

Salicylates (NSAIDs) and cephalosporins presenting the N-methyl-thiotetrazole moiety may reduce the effect of vitamin K1, by inhibition of the vitamin K1 recycling.

Amounts to be administered and administration route:
Slow intravenous injection of 5 mg vitamin K1 per kg body weight (equivalent to 0.5 ml of the product per kg body weight) prior to commencing oral therapy (see Special warnings for each target species). Treatment by injection should be repeated once 12-18 hours later if oral treatment is not immediately possible.

Vomiting has been observed in the dog after the 1st and the 2nd injections, administered 12 hours apart at 3 times the recommended dose (15 mg of vitamin K1 per kg of body weight per injection).

Repeat dosing (10 days) at 7 times the recommended dose of a degraded solution (degradation of lecithin into lysolecithin is observed with time during the storage of the product) caused intravascular haemolysis, involving marked anaemia and vomiting.

Pharmacodynamic properties:
Vitamin K1 is a cofactor necessary for the synthesis of K-dependent coagulation factors (factors II, VII, IX and X). During this synthesis, vitamin K1 is converted into vitamin K1 hydroquinone (active form of vitamin K1) and then into vitamin K1 epoxide. It is then recycled back into vitamin K1. Antivitamin K rodenticides inhibit the recycling of vitamin K1 epoxide, causing a risk of uncontrolled bleeding through the absence of functional factors II, VII, IX and X synthesis. The supply of vitamin K1 must be sufficiently large to activate hydrogenase enzyme that converts it to its active (hydroquinone) form.

Pharmacokinetic properties:
After intravenous administration at 5 mg/kg in the dog, the following pharmacokinetic parameters were obtained: Cmax=85.2 µg/ml, AUC=4246 µg/min/ml, T½=179.5 min, Cl=1.15 ml/min, a bioavailability of 100% and a distribution volume estimated at 4×10-4 ml.

One hour after intravenous administration, vitamin K1 is detected in the liver (90% unchanged) before being distributed throughout the body. Some of the vitamin K1 is eliminated with the bile in the intestinal tract after metabolism in the liver, and some is eliminated in urine (in the form of glucuronoconjugated metabolites).

Pharmaceutical particulars:
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Use immediately after opening.

Special precautions for storage:
Protect from light. Do not store above 25°C. Any solution remaining in the ampoule following withdrawal of the required dose should be discarded. Keep out of the sight and reach of children.

Immediate packaging:
5 ml amber clear glass ampoules, type I.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Shipping charges mainland GB zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250 grams £3.49

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.

Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

We no longer send goods outside of the UK.

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or express delivery at a cost of £7.50, with coolpacks, unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

Related Products