Vetivex 1 (9 mg/ml) Solution for Infusion

Vetivex 1 (9 mg/ml) Solution for Infusion for Cattle, Horses, Dogs and Cats.

Target species:
Cattle, horses, dogs and cats.

Indications for use:
This product is administered by intravenous infusion for the treatment of dehydration in cattle, horses, dogs and cats. It may be used to correct hypovolaemia resulting from shock or gastrointestinal disease (especially where metabolic alkalosis is present, e.g. in cases of sustained vomiting or abomasal disorders in cattle). It may be administered to meet normal fluid and electrolyte requirements when fluids cannot be given orally.

Special precautions for use in animals:
Do not use unless the solution is clear, free from visible particles and the container is undamaged. Sodium overload may occur in animals with cardiac or renal impairment. It should be noted that sodium excretion may be impaired post-surgery/trauma.

A risk of thrombosis with intravenous infusion should be considered.

The product should be warmed to approximately 37°C prior to the administration of large volumes, or if the administration rate is high, in order to avoid hypothermia.

This product should not be used for longer than is necessary to correct and sustain circulating volume. Inappropriate/excessive use may worsen or create a metabolic acidosis.

Maintain aseptic precautions.

Adverse reactions:
Excessive infusion rates can cause restlessness, moist lung sounds, tachycardia, tachypnoea, nasal discharge, coughing, vomiting and diarrhoea.

Use during pregnancy and lactation:
Use under veterinary supervision.

Amounts to be administered and administration route:
Intravenous use.

The volume and rate of infusion will depend upon the clinical condition, existing deficits of the animal, maintenance needs and continuing losses.

Generally aim to correct hypovolaemia by 50% initially (ideally over 6 hours but faster if necessary) and reassess by clinical examination.

Deficits are generally in the range of 50 ml/kg (mild) to 150 ml/kg (severe). An infusion rate of 15 ml/kg/hour is recommended in the absence of shock (range 5-75 ml/kg/hour).

In shock, high initial infusion rates, up to 90 ml/kg/hour, are needed. High infusion rates should not be continued for longer than 1 hour unless urine output is restored. The maximum infusion rate should be decreased in the presence of cardiac, renal and pulmonary disease.

Overdose:
Monitor fluid output. The administration of a diuretic may be necessary.

Withdrawal periods:
Cattle and horses: Meat and offal/milk - zero days/hours.

Pharmacodynamic properties:
The intravenous infusion is used to replace depleted water and electrolytes when fluids cannot be given orally. It will restore extracellular volume (including plasma volume) and, where metabolic alkalosis is present, it will help to correct it.

Pharmacokinetic properties:
Intravenous infusion ensures rapid distribution. The constituents of the infusion solution will be metabolised and excreted through the same pathways as those substances derived from normal dietary sources.

Pharmaceutical particulars:
Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale:
100 ml: 18 months
500 ml, 1000 ml and 2000 ml: 2 years

The product should be used immediately and not stored after opening.

Special precautions for storage:
Do not store above 25°C.
Do not freeze.

Immediate packaging:
Polyvinylchloride infusion bag overwrapped with polypropylene.

Pack sizes: Individual fluid bags of 100 ml, 500 ml, 1000 ml and 2000 ml, each supplied with a package leaflet, or boxes containing 50 x 100 ml, 20 x 500 ml, 10 x 1000 ml, 4 x 2000 ml.

Not all pack sizes may be marketed.

Disposal:
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.