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Sensiblex 40mg/ml solution for injection for cattle 50ml POM

Sensiblex 40mg/ml solution for injection for cattle promotes dilation of the soft tissues of the birth canal in cases where the birth canal is insufficiently opened.
Prescription Medicine
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Sensiblex 40mg/ml solution for injection for cattle 50ml.

Target species
Cattle (cows, heifers)

Indications for use, specifying the target species
Cows, heifers:
- Promotes dilation of the soft tissues of the birth canal in cases where the birth canal is insufficiently opened.
- Regulates uterine contractions in animals with hypertonic muscular contractions of the uterus.
- Promotes dilation of the soft tissues of the birth canal to facilitate parturition.

Do not administer in cases of mechanical obstetrical disorders.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species
The product is ineffective if no part of the foetus has entered the cervical canal and if abdominal pressing has not started.
Before administering the product it is important to ensure there are no mechanical obstructions (e.g. oversized foetus). If present, obstructions must be removed prior to product administration (e.g. correction of abnormal presentation or uterine torsion).

Special precautions for use
Special precautions for use in animals

Special precautions to be taken by the person administering the veterinary medicinal product to animals

The product has a potential to affect uterine musculature. Therefore, pregnant women and those women who are attempting to conceive should not handle or administer the product.
Administration should be performed with caution in order to avoid accidental self-injection.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
Accidental spillage onto skin or into the eyes should be thoroughly rinsed off with water.
People with known hypersensitivity to denaverine hydrochloride or to any of the excipients should not administer the product.
Wash hands after use.

Adverse reactions (frequency and seriousness)
Increased restlessness; swellings at the injection site; absent or insufficient effectiveness necessitating further obstetric measures.

Use during pregnancy, lactation or lay
Use at the time of parturition only. Not for use during other stages of pregnancy or during lactation.

Interaction with other medicinal products and other forms of interaction
The product should not be mixed with other veterinary medicinal products. In the case of additional administration of oxytocin or its analogues, the dose of this active substance must be carefully selected because denaverine may amplify its effects.

Amounts to be administered and administration route
For intramuscular use.

Heifers: 10.0 ml product (400 mg Denaverine hydrochloride / animal)
Cows:  10.0 ml product (400 mg Denaverine hydrochloride / animal)

Timing of product administration:

- Use in heifers to facilitate parturition: the product should be administered as soon as parts of the foetus are within the cervical canal and abdominal pressing has started.

- Use in heifers and cows to promote dilation of the soft tissues of the birth canal: the product can be administered immediately after the veterinary surgeon has determined that insufficient opening of the soft birth canal is present (please also refer to section 4.3 [contraindications] and 4.4 [special warnings] of the SPC).

In cases where full dilation is not achieved, product administration may be repeated once after 40 - 60 minutes.

Overdose (symptoms, emergency procedures, antidotes), if necessary
In case of overdose or intravenous application, anticholinergic effects, e.g. increased heart and decreased respiration rate may occur. Do not exceed the recommended dose.

Withdrawal period(s)
Cattle:   Meat and offal: 1 day
 Milk:   24 hours

Pharmacotherapeutic group: Genitourinary system and sex hormones; other gynaecologicals
ATCvet code: QG02CX90

Pharmacodynamic properties
Denaverine hydrochloride is a spasmolytic agent with a relaxant effect on smooth muscle. It has a relaxing effect on the uterus sub partu and increases the distensibility of the soft-tissue of the birth canal. Following intramuscular injection the spasmolytic effect commences within 15 to 30 minutes and lasts for several hours. The mechanism of action is not known.

Pharmacokinetic particulars
Denaverine is excreted rapidly from the treated animals.

List of excipients
Benzyl alcohol (E1519)
Propylene glycol
Hydrochloric acid (for pH adjustment)
Water for injections

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf life of the veterinary medicinal product as packaged for sale:
2 years
Shelf life after first opening the immediate packaging:
28 days

Special precautions for storage
This veterinary medicinal product does not require any special storage conditions.

Nature and composition of immediate packaging
Vial of colourless glass, type I, with a fluorinated bromobutyl rubber stopper and an aluminium cap;

1 vial (10 ml) in a cardboard box.
1 vial (50 ml) in a cardboard box.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Shipping charges mainland UK zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250g £2.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available.

NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.

Estimated "Usually shipped in" information is shown against most products

Overseas orders

Postage outside of the UK is from £4.50

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or Royal Mail with coolpacks unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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