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Robexera Chewable Tablets for Dogs POM

KRKA UK Limited

Item no: ROBEXER
Prescription Medicine
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£30.35 - £56.39
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For the treatment of pain and inflammation associated with chronic osteoarthritis.
For the treatment of pain and inflammation associated with soft tissue surgery.

Dosage and administration
For oral use. Do not administer with food since clinical trials demonstrated better efficacy of robenacoxib for osteoarthritis when administered without food or at least 30 minutes before or after a meal. Tablets are flavoured. The tablets should not be divided or broken.
Osteoarthritis: The recommended dose of robenacoxib is 1 mg/kg body weight with a range 1–2 mg/kg. Administer once daily at the same time every day according to the table below.
Body Weight (kg)
Number of Tablets by Strength
5 mg
10 mg
20 mg
40 mg
2.5 to < 5
1 tablet
5 to < 10
1 tablet
10 to < 20
1 tablet
20 to < 40
1 tablet
40 to 80
2 tablet
A clinical response is normally seen within a week. Treatment should be discontinued after 10 days if no clinical improvement is apparent. For long-term treatment, once a clinical response has been observed, the dose of robenacoxib can be adjusted to the lowest effective individual dose reflecting that the degree of pain and inflammation associated with chronic osteoarthritis may vary over time. Regular monitoring should be undertaken by the veterinarian.
Soft tissue surgery: The recommended dose of robenacoxib is 2 mg/kg body weight with a range of 2-4 mg/kg. Give as a single oral treatment prior to soft tissue surgery. The tablet(s) should be administered without food at least 30 minutes prior to surgery.
After surgery, once daily treatment may be continued for up to two further days.
Number of Tablets by Strength and Body Weight for Soft Tissue Surgery
Body Weight (kg)
Number of Tablets by Strength
5 mg
10 mg
20 mg
40 mg
1 tablet
>2.5 to < 5
1 tablet
5 to < 10
1 tablet
10 to < 20
1 tablet
20 to < 40
2 tablets
40 to < 60
3 tablets
60 to 80
4 tablets
Adverse events
Very common (>1 animal / 10 animals treated): Gastrointestinal adverse events.1 Vomiting, loose stool.1
Common (1 to 10 animals / 100 animals treated): Decreased appetite.1 Diarrhoea.1 Elevated liver enzymes.2
Uncommon (1 to 10 animals / 1,000 animals treated): Blood in faeces1 , vomiting3 . Anorexia, apathy.3
Very rare (<1 animal / 10,000 animals treated, including isolated reports): Lethargy.
1 Most cases were mild and recovered without treatment.
2 In dogs treated up to 2 weeks no increases in liver enzyme activities were observed. However, with long-term treatment, increases in liver enzyme activities were common. In most cases there were no clinical signs and the liver enzyme activities either stabilised or decreased with continued treatment.
3 Clinical signs associated with increases in liver enzyme activities. Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation or lay
The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Pregnancy and lactation: Do not use during pregnancy and lactation. Fertility: Do not use in breeding animals

Contra-indications, warnings, etc
Do not use in dogs suffering from gastrointestinal ulceration or with hepatic disease.
Do not use concomitantly with corticosteroids or other non-steroidal anti-inflammatory drugs (NSAIDs).
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not use in pregnant and lactating animals (see section Dosage and Administration).
Special warnings for each target species
In clinical studies in dogs with osteoarthritis, inadequate response to treatment was seen in 10-15% of the dogs.
Special precautions for use
i)Special precautions for use in animals The safety of the veterinary medicinal product has not been established in dogs weighing less than 2.5 kg or under 3 months of age. For long term therapy, liver enzymes should be monitored at the start of therapy, e.g. after 2, 4 and 8 weeks. Thereafter it is recommended to continue regular monitoring, e.g. every 3-6 months. Therapy should be discontinued if liver enzyme activities increase markedly or the dog shows clinical signs such as anorexia, apathy or vomiting in combination with elevated liver enzymes. Use in dogs with impaired cardiac or renal function or dogs that are dehydrated, hypovolaemic or hypotensive may involve additional risks. If use cannot be avoided, these dogs require careful monitoring. Use this product under strict veterinary monitoring in dogs with a risk of gastrointestinal ulcers, or if the dog previously displayed intolerance to other NSAIDs. Tablets are flavoured. In order to avoid any accidental ingestion, store tablets out of reach of the animals.
ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals For pregnant women, particularly near-term pregnant women, prolonged dermal exposure increases the risk of premature closure of the ductus arteriosus in the foetus. Pregnant women should take special care to avoid accidental exposure. Accidental ingestion increases the risk for NSAID adverse effects, particularly in small children. Care should be taken to avoid accidental ingestion by children. In order to prevent children from accessing the product, do not remove tablets from the blister until ready to administer to the animal. Tablets should be administered and stored (in the original packaging) out of sight and reach of children. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands after use of the veterinary medicinal product. Special precautions for the protection of the environment: Not applicable.
iii)Other precautions Not applicable.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In healthy young dogs aged 5-6 months, oral robenacoxib administered at high overdoses (4, 6 or 10 mg/kg/day for 6 months) did not produce any signs of toxicity, including no evidence of any gastrointestinal, kidney or liver toxicity and no effect on bleeding time. Robenacoxib also had no detrimental effects on cartilages or joints.
As with any NSAID, overdose may cause gastrointestinal, kidney, or liver toxicity in sensitive or compromised dogs. There is no specific antidote. Symptomatic, supportive therapy is recommended consisting of administration of gastrointestinal protective agents and infusion of isotonic saline.
The use of robenacoxib tablets in mongrel dogs at overdoses of up to 3 times the maximum recommended dose (2.0, 4.0 and 6.0 plus 4.0, 8.0 and 12.0 mg robenacoxib/kg orally) resulted in inflammation, congestion or haemorrhage in the duodenum, jejunum and caecum. No relevant effects on body weight, bleeding time or evidence of any kidney or liver toxicity were observed.

Pharmaceutical precautions
Interaction with other medicinal products and other forms of interaction
Interaction with other medicinal products and other forms of interaction Robenacoxib must not be administered in conjunction with other NSAIDs or glucocorticoids. Pre-treatment with other anti-inflammatory medicines may result in additional or increased adverse effects and accordingly a treatment-free period with such substances should be observed for at least 24 hours before the commencement of treatment with robenacoxib. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously.
Concomitant treatment with medicines displaying action on renal flow, e.g. diuretics or angiotensin-converting enzyme (ACE) inhibitors, should be subject to clinical monitoring. In healthy dogs treated with and without the diuretic furosemide, concomitant administration of robenacoxib with the ACE inhibitor benazepril for 7 days was not associated with any negative effects on urine aldosterone concentrations, plasma renin activity or glomerular filtration rate. No safety data in the target population and no efficacy data in general exist for the combined treatment of robenacoxib and benazepril.
Concurrent administration of potentially nephrotoxic medicines should be avoided as there might be an increased risk of renal toxicity.
Concurrent use of other active substances that have a high degree of protein binding may compete with robenacoxib for binding and thus lead to toxic effects.
Major Incompatibilities
Not applicable.
List of excipients:
Cellulose microcrystalline, Povidone, Crospovidone, Yeast powder, Meat flavour, Silica, colloidal anhydrous, Magnesium stearate

Legal category
Legal category:POM-V

Packaging quantities
Robexera 5 mg / 10 mg / 20 mg / 40 mg chewable tablets for dogs - boxes of 30 tablets, in 3 x blisters of 10 tablets

Pack of 30

Shipping charges mainland GB zone1

Value Weight Delivery Charge
Over £49.00 Any Weight FREE
Under £49.00 No weight limit £4.50
Under £49.00 Under 250 grams £3.49

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.

Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.

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Overseas orders

We no longer send goods outside of the UK.

Prescription Items

Prescription items will be sent on receipt of a valid signed and dated prescription.

Pick up

We offer a pickup service for orders placed over the phone.

Please ring us on 01833 641112 for more information.

Refrigerated Items

Refrigerated items will be sent by carrier or express delivery at a cost of £7.50, with coolpacks, unless you pay for a premium for a refrigerated delivery. We will contact you prior to despatch for your instructions.

We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.

*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.

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