Soliphen tablets are flavoured, easily divisible into 15mg increments for more accurate dosing, and blister packed for convenience. Not only that but, unique among phenobarbital generics, Soliphen has proven bioequivalence to the market leading brand allowing an on-label medication swap where necessary or desirable for stable epileptic patients already being treated. Off course, it also offers an attractive first-line and effective treatment option for newly diagnosed epileptic dogs.
Each tablet contains 60mg phenobarbital
Oblong, white spotted tablet, with 3 scored lines. The tablets can be divided into two or four equal parts.
The decision to start antiepileptic drug therapy with phenobarbital should be evaluated for each individual case and depends on number, frequency, duration and severity of seizures in dogs.
The required dosage will differ to some extent between individuals and with the nature and severity of the disorder.
Dogs should be dosed orally, starting with a dose of 2-5 mg per kg bodyweight per day. The dose should be divided and administered twice daily. The tablet can be divided into equal halves and quarters to provide 30 mg and 15 mg doses, respectively.
Tablets must be given at the same time each day to achieve successful therapy.
Steady state serum concentrations are not reached until 1-2 weeks after treatment is initiated. The full effect of the medication does not appear for two weeks and doses should not be increased during this time.
If seizures are not being controlled, the dosage may be increased by 20% at a time, with associated monitoring of serum phenobarbital levels. The phenobarbital serum concentration may be checked after steady state has been achieved, and if it is less than 15 µg/ml the dose may be adjusted accordingly. If seizures recur the dose may be raised up to a maximum serum concentration of 45 µg/ml. High plasma concentrations may be associated with hepatotoxicity.
Blood samples could be taken at the same time to allow plasma phenobarbital concentration to be determined preferably during trough levels, shortly before the next dose of phenobarbital is due.
If the seizures are not being satisfactorily prevented and if the maximum level concentration is about 40 µg/ml, then the diagnosis should be reconsidered and/or a second antiepileptic product (such as bromides) should be added to the treatment protocol.
Plasma concentrations should be interpreted in conjunction with the observed response to therapy and a full clinical assessment including monitoring for evidence of toxic effects in each animal.
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