Moduretic tablets (pack of 28) POM
Potassium-conserving diuretic and antihypertensive.
'Moduretic' is indicated in patients with: hypertension, congestive heart failure, hepatic cirrhosis with ascites and oedema. In hypertension, 'Moduretic' may be used alone or in conjunction with other antihypertensive agents.
'Moduretic' is intended for the treatment of patients in whom potassium depletion might be suspected or anticipated. The presence of amiloride hydrochloride minimises the likelihood of potassium loss during vigorous diuresis for long-term maintenance therapy. The combination is thus indicated especially in conditions where potassium balance is particularly important.
Posology and method of administration
Posology
Hypertension
Initially half a 'Moduretic' tablet given once a day. If necessary, increase to one 'Moduretic' tablet given once a day or in divided doses.
Congestive heart failure
Initially half a 'Moduretic' tablet a day, subsequently adjusted if required, but not exceeding two 'Moduretic' tablets a day. Optimal dosage is determined by the diuretic response and the plasma potassium level. Once an initial diuresis has been achieved, reduction in dosage may be attempted for maintenance therapy. Maintenance therapy may be on an intermittent basis.
Patients with hepatic cirrhosis with ascites
Initiate therapy with a low dose. A single daily dose of one 'Moduretic' tablet may be increased gradually until there is an effective diuresis. Dosage should not exceed two 'Moduretic' tablets a day. Maintenance dosages may be lower than those required to initiate diuresis; dosage reduction should therefore be attempted when the patient's weight is stabilised. A gradual weight reduction is especially desirable in cirrhotic patients to reduce the likelihood of untoward reactions associated with diuretic therapy.
Paediatric population
Moduretic is contraindicated in children under 18 years because safety and efficacy have not been established (see section 4.3).
Elderly patients
Particular caution is needed in the elderly because of their susceptibility to electrolyte imbalance; the dosage should be carefully adjusted to renal function and clinical response.
Method of administration
Oral use
For Full Date Sheet: https://www.medicines.org.uk/emc/product/1653/smpc
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