Dexdomitor 0.5 mg/ml Solution for Injection 10ml.
Dexdomitor 0.5mg/ml is indicated for use in dogs and cats as follows:
•Non-invasive, mildly to moderately painful procedures and examinations which require restraint, sedation and analgesia in dogs and cats.
•Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures.
•Premedication in dogs and cats before induction and maintenance of general anaesthesia.
Dosage and administration
The product is intended for:
- Dogs: intravenous or intramuscular use
- Cats: intramuscular use
The product is not intended for repeat injections.
Dexdomitor, butorphanol and/or ketamine can be mixed in the same syringe as they have been shown to be pharmaceutically compatible.
It is recommended that animals are fasted for 12 hours prior to administration. Water may be given ad libitum.
DOGS:
The doses for dogs are based on body surface area. The intravenous dose is up to 375 micrograms/square metre body surface area and the intramuscular dose is up to 500 micrograms/square metre body surface area when dexmedetomidine is used as the only agent for sedation and analgesia.
When administering in conjunction with butorphanol (0.1 mg/kg) for deep sedation and analgesia, the intramuscular dose is 300 micrograms/square metre body surface area. The premedication dose of dexmedetomidine is 125 – 375 micrograms/square metre body surface area, administered 20 minutes prior to induction for procedures requiring anaesthesia. The dose should be adjusted to the type of surgery, length of procedure and patient temperament.
Concomitant use of dexmedetomidine and butorphanol produces sedative and analgesic effects beginning no later than 15 minutes after administration. The peak sedative and analgesic effects are reached within 30 minutes after administration. Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes. Spontaneous recovery occurs within 3 hours.
Premedication with dexmedetomidine will significantly reduce the dosage of the induction agent required and will reduce volatile anaesthetic requirements for maintenance anaesthesia. In a clinical study, the requirement for propofol and thiopental was reduced by 30% and 60% respectively. All anaesthetic agents used for induction or maintenance of anaesthesia should be administered to effect. In a clinical study, dexmedetomidine contributed to postoperative analgesia for 0.5 - 4 hours. However this duration is dependent on a number of variables and further analgesia should be administered in accordance with clinical judgement.
The corresponding doses based on body weight are presented in the following tables. Use of an appropriately graduated syringe is recommended to ensure accurate dosing when administering small volumes.
Dogs
| Dogs | Single-use sedation and analgesia | |||
| Weight | Dexdomitor 0.5mg/ml - 375 mcg/m2 | Dexdomitor 0.5mg/ml - 500 mcg/m2 | ||
| (kg) | (mcg/kg) | (ml) | (mcg/kg) | (ml) |
| 2-3 | 28.1 | 0.12 | 40 | 0.15 |
| 3-4 | 25 | 0.17 | 35 | 0.2 |
| 4-5 | 23 | 0.2 | 30 | 0.3 |
| 5-10 | 19.6 | 0.29 | 25 | 0.4 |
| 10-13 | 16.8 | 0.38 | 23 | 0.5 |
| 13-15 | 15.7 | 0.44 | 21 | 0.6 |
| 15-20 | 14.6 | 0.51 | 20 | 0.7 |
| 20-25 | 13.4 | 0.6 | 18 | 0.8 |
| 25-30 | 12.6 | 0.69 | 17 | 0.9 |
| 30-33 | 12 | 0.75 | 16 | 1.0 |
| 33-37 | 11.6 | 0.81 | 15 | 1.1 |
| 37-45 | 11 | 0.9 | 14.5 | 1.2 |
| 45-50 | 10.5 | 0.99 | 14 | 1.3 |
| 50-55 | 10.1 | 1.06 | 13.5 | 1.4 |
| 55-60 | 9.8 | 1.13 | 13 | 1.5 |
| 60-65 | 9.5 | 1.19 | 12.8 | 1.6 |
| 65-70 | 9.3 | 1.26 | 12.5 | 1.7 |
| 70-80 | 9 | 1.35 | 12.3 | 1.8 |
| >80 | 8.7 | 1.42 | 12 | 1.9 |
| Dogs | For deep sedation and analgesia with butorphanol | For premedication prior to general anaesthesia | ||||
| Weight | Dexdomitor 0.5mg/ml - 300 mcg/m2intramuscularly | Dexdomitor 0.5mg/ml - 125 mcg/m2 | Dexdomitor 0.5mg/ml - 375 mcg/m2 | |||
| (kg) | (mcg/kg) | (ml) | (mcg/kg) | (ml) | (mcg/kg) | (ml) |
| 2-3 | 24 | 0.12 | 9.4 | 0.04 | 28.1 | 0.12 |
| 3-4 | 23 | 0.16 | 8.3 | 0.05 | 25 | 0.17 |
| 4-5 | 22.2 | 0.2 | 7.7 | 0.07 | 23 | 0.2 |
| 5-10 | 16.7 | 0.25 | 6.5 | 0.1 | 19.6 | 0.29 |
| 10-13 | 13 | 0.3 | 5.6 | 0.13 | 16.8 | 0.38 |
| 13-15 | 12.5 | 0.35 | 5.2 | 0.15 | 15.7 | 0.44 |
| 15-20 | 11.4 | 0.4 | 4.9 | 0.17 | 14.6 | 0.51 |
| 20-25 | 11.1 | 0.5 | 4.5 | 0.2 | 13.4 | 0.6 |
| 25-30 | 10 | 0.55 | 4.2 | 0.23 | 12.6 | 0.69 |
| 30-33 | 9.5 | 0.6 | 4 | 0.25 | 12 | 0.75 |
| 33-37 | 9.3 | 0.65 | 3.9 | 0.27 | 11.6 | 0.81 |
| 37-45 | 8.5 | 0.7 | 3.7 | 0.3 | 11 | 0.9 |
| 45-50 | 8.4 | 0.8 | 3.5 | 0.33 | 10.5 | 0.99 |
| 50-55 | 8.1 | 0.85 | 3.4 | 0.35 | 10.1 | 1.06 |
| 55-60 | 7.8 | 0.9 | 3.3 | 0.38 | 9.8 | 1.13 |
| 60-65 | 7.6 | 0.95 | 3.2 | 0.4 | 9.5 | 1.19 |
| 65-70 | 7.4 | 1 | 3.1 | 0.42 | 9.3 | 1.26 |
| 70-80 | 7.3 | 1.1 | 3 | 0.45 | 9 | 1.35 |
| >80 | 7 | 1.2 | 2.9 | 0.47 | 8.7 | 1.42 |
CATS:
The dosage for cats is 40 micrograms dexmedetomidine hydrochloride/kg bw equal to a dose volume of 0.08 ml Dexdomitor 0.5mg/ml /kg bw when used for non-invasive, mildly to moderately painful procedures requiring restraint, sedation and analgesia. When dexmedetomidine is used for premedication in cats, the same dose is used. Premedication with dexmedetomidine will significantly reduce the dosage of the induction agent required and will reduce volatile anaesthetic requirements for maintenance anaesthesia. In a clinical study, the requirement for propofol was reduced by 50%. All anaesthetic agents used for induction or maintenance of anaesthesia should be administered to effect.
Anaesthesia can be induced 10 minutes after premedication by intramuscular administration of a target dose of 5 mg ketamine/kg bw or by intravenous administration of propofol to effect. Dosing for cats is presented in the table below.
Cats
| Cats | For single-use sedation and analgesia or for premedication | |
| Weight | Dexdomitor 0.5mg/ml - 40 mcg/kg intramuscularly | |
| (kg) | (mcg/kg) | (ml) |
| 1-2 | 40 | 0.1 |
| 2-3 | 40 | 0.2 |
| 3-4 | 40 | 0.3 |
| 4-6 | 40 | 0.4 |
| 6-7 | 40 | 0.5 |
| 7-8 | 40 | 0.6 |
| 8-10 | 40 | 0.7 |
The expected sedative and analgesic effects are reached within 15 minutes after administration and are maintained up to 60 minutes after administration. Sedation may be reversed with atipamezole. Atipamezole should not be administered prior to 30 minutes following ketamine administration.
Administration of atipamezole after dexmedetomidine rapidly reverses the effects and thus shortens the recovery period. Within 15 minutes dogs and cats are normally awake and standing.
Cats: After administration of 40 micrograms dexmedetomidine/ kg bw intramuscularly concurrently with 5 mg ketamine /kg bw to cats, the maximum concentration of dexmedetomidine increased two-fold but there was no effect on T max. The mean half-life of elimination of dexmedetomidine increased to 1.6 hours and the total exposure (AUC) increased by 50%.
A dose of 10 mg ketamine/ kg used concurrently with 40 micrograms dexmedetomidine/ kg may cause tachycardia.
Packaging Quantities
Dexdomitor 0.5mg/ml Solution for Injection is available in 10 ml glass vials.
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