Target species
Cattle and pigs.
Indications for use
Cattle: For the treatment of respiratory infections caused by oxytetracycline susceptible organisms such as Arcanobacterium (Actinomyces) pyogenes and Haemophilus somnus.
Pigs: For the treatment of respiratory infections caused by oxytetracycline susceptible organisms such as Pasteurella multocida.
Contraindications
Hypersensitivity to tetracyclines. The use of oxytetracycline in animals with an impaired liver and/or kidney function should be avoided.
Special precautions for use in animals
It is strongly recommended to divide the intramuscular dosages over two or more injection sites (see posology).
For the 250 ml pack, the use of a multidose syringe is recommended. To refill the syringe, the use of a draw off needle is recommended to avoid excessive broaching of the stopper.
It is recommended to use Cyclosol LA in the early stages of disease and to evaluate the response to treatment within 72 hours.
Resistance against oxytetracycline may vary. Use of the product should be based on susceptibility testing and taking into account official and local antimicrobial policies.
Inappropriate use of the product may increase the prevalence of bacteria resistant to oxytetracycline and may decrease the effectiveness of treatment with tetracyclines due to the potential for cross resistance.
Because oxytetracycline can retard skeletal development and may cause discoloration and enamel hypoplasia of fetal teeth, the product should be used cautiously in the last half of pregnancy.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Persons with a known hypersensitivity to tetracyclines should not handle this product. The direct or indirect contact of the user via skin or mucosa should be avoided because of the risk of sensitisation. Wash hands after use. In case of contact with eyes or skin, wash immediately with water as irritation may occur.
Adverse reactions
Hypersensitivity reactions (cattle), hepatotoxicity and haematologic effects have been reported, but are rare. In case of a serious anaphylactic reaction in cattle the administration of epinephrine, antihistamines and corticosteroids should be considered
Treated animals, particularly those with poor skin pigmentation, may develop photodermatitis when exposed to intensive sunlight. Following intramuscular administration a transient swelling and/or yellow staining (and local necrosis) will occur at the site of the injection. Swelling will be visible for several days after injection. Following injection a small drop in milk production may be observed in lactating animals for up to 3 days.
Use during pregnancy and lactation
The placenta is readily passed by oxytetracycline and concentration in the foetal blood may reach those of the maternal circulation, although concentration is usually somewhat lower. The product is not recommended in the last 2-3 weeks of pregnancy
Tetracyclines are deposited in deciduous and permanent teeth causing discoloration, enamel hypoplasia, and reduced mineralisation. Tetracyclines can retard fetal skeletal development. Oxytetracycline is excreted in the milk; concentrations are generally low.
Interactions
Oxytetracycline should not be administered simultaneously with penicillins or cephalosporins.
Amounts to be administered and administration route
The product is indicated for (deep) intramuscular injection. It is strongly recommended to divide the intramuscular dosages over two or more injection sites - maximum 15 ml per injection site in cattle over 150 kg body weight and 7 ml in pigs and calves. Injection sites should be alternated.
Pigs: 20 mg oxytetracycline per kg body weight, if necessary repeat after 72 hours
Cattle not producing milk for human consumption:
20 mg oxytetracycline per kg body weight, if necessary repeat after 72 hours
Cattle producing milk for human consumption:
20 mg oxytetracycline per kg body weight as a single injection only
Overdose
After intramuscular administration of the antibiotic in lethal dosages, central nervous system symptoms as excitation and convulsions, followed by depression, generalized muscular paralysis and respiratory arrest, preceding death were observed (death usually occurs through respiratory failure). Long-term treatment may result in gastrointestinal disturbances and changes of gut flora (supra-infections). High dosages or chronic administration of oxytetracycline may delay bone growth and healing in young animals. Chronic overdose may lead to drug accumulation and nephrotoxicity. There are no known antidotes to oxytetracycline toxicity.
Withdrawal periods
Cattle: meat and offal: 35 days; milk: 8 days.
Pigs: meat and offal: 28 days.
Pharmacological particulars
Pharmacotherapeutic group: Tetracycline antimicrobial
ATCvet code: QJ01AA06
Pharmacodynamic properties
Oxytetracycline is a bacteriostatic antibiotic. It exerts its action by inhibiting the protein synthesis of the bacterial cell. Inhibition of bacterial protein synthesis results in disturbance of all functions necessary for the life of bacteria, especially cell-division, and the formation of the cell wall are impaired.
Resistance is usually plasmid-mediated. Micro-organisms that have become resistant to one tetracycline frequently exhibit resistance to the others.
Pharmacokinetic properties
Absorption of oxytetracycline following intramuscular injection of CYCLOSOL LA is fast. In pigs the Cmax is measured within 2-3 hours; the Cmax is approximately 4 µg/ml. In cattle absorption is somewhat slower; the Cmax is measured after 3-5 hours; the Cmax is approximately 3-6 µg/ml.
A plasma concentration of 0.5 µg/ml or more is maintained for 72 hours in cattle and pigs. Concentrations of 0.1 µg/ml are maintained for 5 days. Bioavailability of CYCLOSOL LA is approximately 100%.
High concentrations of oxytetracycline are detectable in kidney, liver, and urine, but oxytetracycline is widely distributed in the body, including lungs and muscle. The placenta is readily passed by oxytetracycline and concentration in the foetal blood may reach that of the maternal circulation.
Oxytetracycline apparently is not metabolized in vivo and is eliminated primarily unchanged, via glomerular filtration. It is also excreted into the GI tract via both biliary and nonbiliary routes and may become inactive after chelation with faecal material.
Pharmaceutical particulars
Incompatibilities
In the absence of compatibility studies this veterinary medicinal product must not be mixed with other veterinary medicinal products in the same syringe.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
Shelf life after first opening the container: 14 days.
Special precautions for storage
Do not freeze. Keep container in the outer carton.
Immediate packaging
Amber coloured, glass type II vials containing 50/100/250 ml solution for injection. Not all pack sizes may be marketed.
Disposal
Any unused product or waste material should be disposed of in accordance with national requirements.
Shipping charges mainland GB zone1
| Value | Weight | Delivery Charge |
| Over £49.00 | Any Weight | FREE |
| Under £49.00 | No weight limit | £4.50 |
| Under £49.00 | Under 250 grams | £3.49 |
Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.
Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.
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Estimated "Usually shipped in" information is shown against most products
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We no longer send goods outside of the UK.
Prescription Items
Prescription items will be sent on receipt of a legally valid signed and dated prescription.
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We offer a pickup service for orders placed over the phone.
Please ring us on 01833 641112 for more information.
Refrigerated Items
- Refrigerated lines Packaging Cost: Despatched with Woolcool Refrigerated Packaging for £7.50.
- Receipt Required: Someone must be available to receive the delivery. Woolcool packaging is designed for temperature-controlled goods, so parcels cannot be left unattended.
- Immediate Refrigeration: Upon receipt, refrigerate the contents immediately to ensure your food or medicine remains at the correct temperature.
- Failed Delivery Attempts: We are not responsible for the cost of replacements if a delivery attempt fails due to the absence of someone to receive it.
We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.
*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.
