For the induction of luteolysis allowing resumption of oestrus and ovulation in cycling female cattle when used during dioestrus; synchronisation of oestrus (within 2 to 5 days) in groups of cycling females treated simultaneously; treatment of suboestrus and uterine disorders related to a functional or persistent corpus luteum (endometritis, pyometra); treatment of ovarian luteal cysts; induction of abortion until day 150 of pregnancy; expulsion of mummified foetuses; induction of parturition.
For all indications: 2 ml corresponding to 0.5 mg cloprostenol/animal, injected intramuscularly.
In order to synchronise oestrus in groups of female cattle, it is recommended that the product is administered on two occasions with a treatment interval of 11 days.
Contra-indications, warnings, etc
Do not use in pregnant animals, for which induction of abortion or parturition is not intended. Do not use in animals with spastic diseases of the respiratory or gastrointestinal tract.
To reduce the risk of anaerobic infections, which might be related to the pharmacological properties of prostaglandins, care should be taken to avoid injection through contaminated areas of skin. Clean and disinfect injection sites thoroughly before application. Infection may occur if anaerobic bacteria penetrate the tissue at injection site.
When used for induction of parturition and dependent on the time of treatment relative to the date of conception, the incidence of retained placenta may be increased.
In very rare cases, anaphylactic-type reactions can be observed which might be life-threatening and require rapid medical care.
The product can be safely used during lactation.
Concurrent use of oxytocin and cloprostenol increases the effect on the uterus.
Therapeutic tolerance in cattle is broad. Overdoses of more than 10 times are generally well tolerated. Large overdoses may cause transient diarrhoea. No antidotes are available.
An overdose will not accelerate corpus luteum regression.
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
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