Cobactan MC (pack of 30).
Target species:
Lactating cows
Indications for use, specifying the target species:
For the treatment of clinical mastitis in the lactating dairy cow caused by bacteria susceptible to cefquinome
Contra-indications:
Not to be administered to animals which are known to be hypersensitive to cephalosporin antibiotics.
There may be cross sensitivity to penicillins.
Special warning for each target species:
None.
Special precautions for use:
Special precautions for use in animals:
None
Special precautions to be taken by the person administering the medicinal product to the animals:
When infusing heifers protective gloves should always be worn in order to avoid skin contact.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work which such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the Doctor this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
Adverse reactions (frequency and seriousness):
None known.
Use during pregnancy or lactation:
The product is intended for use during lactation. No restrictions apply for use during pregnancy.
Interaction with other medicinal products and other forms of interaction:
There is a cross sensitivity between the various cephalosporins.
Amounts to be administered and administration route:
The contents of one syringe should be infused gently into the teat of the infected quarter every 12 hours after each of three successive milkings.
Milk out the affected quarter(s). After thoroughly cleaning and disinfecting the teat and teat orifice, gently infuse the contents of one syringe into each affected quarter. Disperse the product by gentle massage of the teat and udder of the affected animal.
Further Information:
Combined Therapy
For the treatment of E.coli mastitis, experimental challenge studies have shown that the use of this product in combination with Cobactan 25 mg/ml suspension for injection leads to an improvement in efficacy, particularly in terms of bacterial cure rate.
For combined therapy the following treatment regime should be followed:
Cobactan 25 mg/ml Cobactan MC
1mg cefquinome/kg bw
(2ml/50 kg bw)
24 hours
1mg cefquinome/kg bw
(2ml/50 kg bw)
One syringe gently infused into the teat of the infected quarter
12 hours
One syringe gently infused into the teat of the infected quarter
12 hours
One syringe gently infused into the teat of the infected quarter
Overdose (symptoms, emergency procedures, antidotes), if necessary:
No symptoms expected or emergency procedures required.
Withdrawal period(s):
Animals must not be slaughtered for human consumption during treatment. Cows may not be slaughtered for human consumption until 48 hours after the last treatment.
Milk must not be taken for human consumption during treatment. Milk must be discarded for 84 hours (7 milkings if cows are milked twice daily) after the last treatment. Milk may not be released for human consumption until 96 hours after the last treatment (at the 8th milking if cows are milked twice daily). With other milking routines, the basis of the veterinary surgeon's advice should be that milk may be taken for human consumption only after the same period from the last treatment.
For example, with three times a day milking, milk may be taken for human consumption only at the 12th milking.
When using Cobactan MC and Cobactan 25 mg/ml combination, animals must not be slaughtered for human consumption during treatment. Cows may not be slaughtered for human consumption until 5 days after the last treatment. Milk must not be taken for human consumption during treatment. Milk must be discarded for 84 hours (7 milkings if cows are milked twice daily) after the last treatment. Milk may not be released for human consumption until 96 hours after the last treatment (at the 8th milking if cows are milked twice daily).
PHARMACOLOGICAL PROPERTIES:
ATC Vet Code: QJ51DA92
Pharmacotherapeutic group: Antibacterials for intramammary use, Other
?-lactam antibacterials for intramammary use, Cephalosporins and related substances
Pharmacodynamic properties:
Cefquinome is an antibacterial drug of the cephalosporin group which acts by inhibition of cell wall synthesis. It is characterised by its broad therapeutic spectrum of activity and a high stability against penicillinases and beta-lactamases.
Pharmacokinetic particulars:
In vitro, Cefquinome has antibiotic activity against common Gram negative and Gram positive bacteria including Salmonella spp, Haemophilus spp, Pasteurella spp, Klebsiella spp, Corynebacterium pyogenes, Escherichia coli, A.pleuropneumoniae, Proteus mirabilis, Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis.
The product has been developed to treat clinical mastitis caused by sensitive strains of Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, Escherichia coli and other enterobacteria.
The base disperses readily in milk and allows rapid distribution of Cefquinome.
Cefquinome as a fourth generation cephalosporin combines high cellular penetration and ß-lactamase stability. In contrast to cephalosporins of previous generations, cefquinome is not hydrolysed by chromosomally-encoded cephalosporinases of the Amp-C type or by plasmid mediated cephalosporinases of some enterobacterial species. However, some Extended Spectrum beta-lactamases (ESBL) can hydrolyse cefquinome and cephalosporins of other generations. The potential for resistance development against cefquinome is rather low. High-level resistance to cefquinome would require the coincidence of two genetic modifications, i.e. hyperproduction of specific ß-lactamases as well as decreased membrane permeability.
PHARMACEUTICAL PARTICULARS
List of excipients:
White soft paraffin
Liquid paraffin
Incompatibilities:
None known
Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
Special precautions for storage:
Do not store above 25°C
The syringe must only be used once. Part used syringes should be discarded.
Nature and composition of immediate packaging:
White opaque polyethylene syringe containing 75mg cefquinome in packs of 3, 15, 20, 24 and 30 syringes.
Not all presentations may be marketed.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if appropriate:
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Shipping charges mainland GB zone1
| Value | Weight | Delivery Charge |
| Over £49.00 | Any Weight | FREE |
| Under £49.00 | No weight limit | £4.50 |
| Under £49.00 | Under 250 grams | £3.49 |
Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.
Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.
NB: Orders placed with faster delivery must be placed before 13:00 to ensure same day dispatch (excluding weekends and bank holidays). Please also check on the product page that the items ordered show 'In Stock' otherwise your order will be delayed until the stock becomes available, which in most cases will only be 24hrs.
Estimated "Usually shipped in" information is shown against most products
Overseas orders
We no longer send goods outside of the UK.
Prescription Items
Prescription items will be sent on receipt of a legally valid signed and dated prescription.
Pick up
We offer a pickup service for orders placed over the phone.
Please ring us on 01833 641112 for more information.
Refrigerated Items
- Refrigerated lines Packaging Cost: Despatched with Woolcool Refrigerated Packaging for £7.50.
- Receipt Required: Someone must be available to receive the delivery. Woolcool packaging is designed for temperature-controlled goods, so parcels cannot be left unattended.
- Immediate Refrigeration: Upon receipt, refrigerate the contents immediately to ensure your food or medicine remains at the correct temperature.
- Failed Delivery Attempts: We are not responsible for the cost of replacements if a delivery attempt fails due to the absence of someone to receive it.
We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.
*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.
