Presentation
Hard gelatin capsules, yellow/white, containing 25 mg clindamycin (as Clindamycin Hydrochloride).
Hard gelatin capsules, green/white, containing 75 mg clindamycin (as Clindamycin Hydrochloride).
Hard gelatin capsules, blue/white, containing 150 mg clindamycin (as Clindamycin Hydrochloride).
Hard gelatin capsules, purple, containing 300 mg clindamycin (as Clindamycin Hydrochloride).
Uses
Oral antibiotic for dogs and cats*
* 25 mg only
Dogs
For the treatment of infected wounds and abscesses, and infected mouth cavity and dental infections, caused by or associated with Staphylococcus spp., Streptococcus spp. (except Streptococcus faecalis), Bacteroides spp., Fusobacterium necrophorum, and Clostridium perfringens. To help provide antimicrobial cover during dental procedures.
For the treatment of superficial pyoderma associated with Staphylococcus intermedius.
For the treatment of osteomyelitis, caused by Staphylococcus aureus
Cats
For the treatment of infected wounds and abscesses and infected mouth cavity and dental infections, caused by bacteria sensitive to clindamycin. To help provide antimicrobial cover during dental procedures.
Before Antirobe therapy is initiated, the involved pathogens should be identified and sensitivity to clindamycin established.
Clindamycin has been shown to have in vitro activity against isolates of the following organisms :
Aerobic Gram-positive cocci, including: Staphylococcus intermedius and Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Staphylococcus epidermidis, Streptococcus spp. (except Streptococcus faecalis), Pneumococcus spp.
Anaerobic Gram-negative bacilli, including: Bacteroides spp., Fusobacterium spp.
Anaerobic Gram-positive non-spore-forming bacilli, including: Propionibacterium spp., Eubacterium spp., Actinomyces spp.
Anaerobic and microaerophilic Gram-positive cocci, including: Peptococcus spp., Peptostreptococcus spp., microaerophilic streptococci.
Clostridia: Most Cl.perfringens are susceptible; other species such as Cl. sporogenes and Cl. tertium frequently are resistant to clindamycin.
Mycoplasma species : Most mycoplasma species are susceptible to clindamycin.
Dosage and administration
For oral administration only.
1.For the treatment of infected wounds and abscesses, and infected mouth cavity and dental infections in dogs and cats, administer either:
5.5 mg/kg of bodyweight every 12 hours for 7=n10 days, or
11 mg/kg of bodyweight every 24 hours for 7=n10 days
If no clinical response is seen within 4 days, redetermine the diagnosis. To help provide anti-microbial cover during dental procedures, a 10 day course is recommended. This should be initiated five days before dental therapy and continued for five days thereafter. In dogs, treatment may be extended to a maximum of 28 days based on clinical judgement.
1.For the treatment of superficial pyoderma in dogs, administer either:
5.5 mg/kg of bodyweight every 12 hours
11 mg/kg of bodyweight every 24 hours
Therapy of canine superficial pyoderma is usually recommended for 21 days, with extension of therapy based on clinical judgement.
1.For the treatment of osteomyelitis in dogs, administer:
11 mg/kg of bodyweight every 12 hours for a minimum of 28 days
If no clinical response is seen within 14 days, the treatment should be stopped and the diagnosis redetermined.
Dosage table
Bodyweight Superficial pyoderma1, dental infections, wounds and abscesses Osteomyelitis1
5.5 mg/kg
ev. 12h 11 mg/kg
ev. 24h 11 mg/kg ev.
12h
4.5 kg 1 x 25 mg twice daily 2 x 25 mg once daily 2 x 25 mg twice daily
13.5 kg 1 x 75 mg twice daily 1 x 150 mg once daily 1 x 150 mg twice daily
27.0 kg 1 x 150 mg twice daily 1 x 300 mg once daily 1 x 300 mg twice daily
1 dogs only
Contra-indications, warnings, etc
For animal treatment only.
Keep out of reach of children.
Wash hands after handling capsules.
Contra-indications
The use of Antirobe Capsules is contra-indicated in animals which are hypersensitive to preparations containing clindamycin or lincomycin.
Do not administer to rabbits, hamsters, guinea pigs, chinchillas, horses or ruminants because ingestion of clindamycin by these species may result in severe gastro-intestinal disturbance.
Warnings/Precautions/Side-effects
Clindamycin and erythromycin show parallel resistance. Partial cross-resistance has been demonstrated between clindamycin, erythromycin and other macrolide antibiotics.
Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Antirobe Capsules should be used with caution in animals receiving such agents.
Clindamycin should not be used concomitantly with chloramphenicol or macrolides as they antagonise each other at their site of action at the 50S ribosomal sub-unit.
Vomiting and diarrhoea have occasionally been observed.
Antirobe sometimes causes the overgrowth of non-sensitive organisms such as resistant clostridia and yeasts. In cases of superinfection, appropriate measures must be taken according to the clinical situation.
During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed.
Animals with severe renal and/or very severe hepatic disturbances accompanied by severe metabolic aberrations should be dosed with caution and should be monitored by serum examination during high-dose clindamycin therapy.
While high dose studies in rats suggest that clindamycin is not a teratogen and does not significantly affect the breeding performance of males and females, safety in gestating bitches/queens or breeding male dogs/cats has not been established.
Legal category
POM-V (previously POM).
Packaging Quantities
The 25 mg, 75 mg and 150 mg presentations are provided in plastic tubs containing 150 capsules. The 300 mg presentation is provided in a plastic tub containing a 100 capsules
Further information
Clindamycin hydrochloride is rapidly absorbed from the canine and feline gastro-intestinal tract following oral administration. Effective clindamycin antibacterial serum levels are reached within 30 minutes following administration of the recommended dose.
The maximum dosage which is well tolerated orally by dogs is 300 mg/kg bodyweight. This is 27 times the indicated dosage for treatment of superficial pyoderma, infected wounds, abscesses, mouth cavity and dental infections
Marketing authorisation numbers
25 mg capsules Vm 04188/4035
75 mg capsules Vm 04188/4036 (dog only)
150 mg capsules Vm 04188/4034 (dog only)
300 mg capsules Vm 04188/4077 (dog only)
Shipping charges mainland GB zone1
| Value | Weight | Delivery Charge |
| Over £49.00 | Any Weight | FREE |
| Under £49.00 | No weight limit | £4.50 |
| Under £49.00 | Under 250 grams | £3.49 |
Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited options are available at extra cost - these usually arrive in 24-48hrs from dispatch but delays are possible during busy periods.
Postcodes outside of Zone 1 (including some areas within mainland UK) may incur extra carriage charges due to surcharges imposed by the couriers. These will be calculated on the website at the checkout.
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Estimated "Usually shipped in" information is shown against most products
Overseas orders
We no longer send goods outside of the UK.
Prescription Items
Prescription items will be sent on receipt of a legally valid signed and dated prescription.
Pick up
We offer a pickup service for orders placed over the phone.
Please ring us on 01833 641112 for more information.
Refrigerated Items
- Refrigerated lines Packaging Cost: Despatched with Woolcool Refrigerated Packaging for £7.50.
- Receipt Required: Someone must be available to receive the delivery. Woolcool packaging is designed for temperature-controlled goods, so parcels cannot be left unattended.
- Immediate Refrigeration: Upon receipt, refrigerate the contents immediately to ensure your food or medicine remains at the correct temperature.
- Failed Delivery Attempts: We are not responsible for the cost of replacements if a delivery attempt fails due to the absence of someone to receive it.
We want you to be completely satisfied with any purchase. If not any item* can be returned to us within 14 days of receipt for exchange or refund Please give us a ring for a returns number on 01833 641112 or alternatively email sales@hyperdrug.co.uk to obtain a returns number.
*Due to legal requirements medicines may not be returned except to correct an error in despatch or in response to an "official recall". If an item is believed to be faulty it should be returned for inspection and it may be necessary to forward it to the manufacturers for testing before replacements or refunds can be authorised. This does not infringe legal rights. Please contact our customer services for a "Returns Number" which must appear on the outside of the package or it will not be accepted. We advise customers to use an insured method of shipping and to retain proof of despatch. We may refuse returns on products specially obtained or manufactured to order. Items must be returned unsoiled and unused and sent adequately packed and carriage paid.